B Cells Secrete Inflammatory Cytokines, Type 2 Diabetes
New research from Boston University School of Medicine (BUSM) reveals that B cells regulate obesity-associated inflammation and type 2 diabetes through two specific mechanisms. The study, published in the Proceedings of the National Academy of Sciences, indicates the importance of continuing to explore B cells as a therapeutic target to treat these diseases. Barbara Nikolajczyk, PhD, associate professor of microbiology at BUSM, is the study’s senior author.
The incidence of diabetes continues to rise at alarming rates. Type 2 diabetes, which is a common result of obesity, occurs when the body produces insulin but cannot use it properly (insulin resistance) or the body does not produce enough insulin. The body needs insulin to absorb glucose and generate energy. If the body does not produce and respond to insulin appropriately, it can, over time, lead to various complications such as cardiovascular disease, nerve damage, kidney disease and blindness.
Previous research has shown that B cells, which are white blood cells of the immune system, promote inflammation and can lead to the development of type 2 diabetes, but the mechanisms underlying B cell function were unclear.
The results of this study shed light on that question and indicate that B cells secrete a pro-inflammatory ratio of proteins called cytokines, which directly promote the insulin resistance that characterizes type 2 diabetes. The researchers also demonstrated that B cells directly regulate inflammatory T cells, an immune cell type known to cause insulin resistance in animal models of disease.
“Now that we have identified the specific mechanisms by which B cells promote inflammation, we can help develop novel, targeted approaches to treat type 2 diabetes,” said Nikolajczyk. “Our study supports the continued exploration of FDA-approved B cell depletion drugs, which are known to be generally safe and effective, as novel agents to prevent obesity-associated inflammation and type 2 diabetes.”
Health-e-Solutions comment: We would prefer to find the cause of the inflammation and stop it there instead of using drugs to deplete B cells. Important in this research is the underlying, well-established connection between inflammation and diabetes. #TheRomanDiet and Health-e-Solutions lifestyle are anti-inflammatory. We think that supports the reduction of inflammation in the body thereby minimizing a primary factor in the development and progression of diabetes.
There are many different inflammatory diseases, including diabetes, yet all of them share the same underlying driver: an inappropriate inflammatory response. Inflammation impacts the lives of millions of people around the world. It is an epidemic that has been accelerated by the modern western diet. We were not designed to eat primarily the foods that are found most commonly in today’s society. The rising cost of health care is due, in part, to the drastic rise of chronic inflammatory disease.
It is important that we empower ourselves with the knowledge and tools to fight back. One of the Primary Food Filters we employ to help us select only the best foods for thriving health and better #BloodSugarControl is to determine whether or not a food is inflammatory. Our Primary Food Filters downloadable, printable special report will fully equip you to make the best food and ingredient choices following the Health-e-Solutions lifestyle to help you #MasterDiabetesNaturally.
Journal Reference: J. DeFuria, A. C. Belkina, M. Jagannathan-Bogdan, J. Snyder-Cappione, J. D. Carr, Y. R. Nersesova, D. Markham, K. J. Strissel, A. A. Watkins, M. Zhu, J. Allen, J. Bouchard, G. Toraldo, R. Jasuja, M. S. Obin, M. E. McDonnell, C. Apovian, G. V. Denis, B. S. Nikolajczyk. B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proceedings of the National Academy of Sciences, 2013; DOI:10.1073/pnas.1215840110