Beta Cell Regeneration Happens
AIMS/HYPOTHESIS: We investigated whether there was evidence of attempted beta cell regeneration in the pancreas obtained from an 89 year old patient with recent-onset type 1 diabetes, and if so by what mechanism this occurred.
SUBJECTS, MATERIALS AND METHODS: We examined pancreas tissue from a lean 89-year-old patient (BMI 18.0 kg/m(2)) with recent-onset type 1 diabetes who had had a distal pancreatectomy to remove a low-grade pancreatic intraepithelial neoplasia.
RESULTS: In the tumor-free tissue, the fractional beta cell area was about one-third of that in non-diabetic humans. CD3-positive T lymphocytes and macrophages had infiltrated the majority of the islets. Subclassification of the T cell population revealed a predominance of CD8-positive cells over CD4-positive cells. Beta cell apoptosis was greatly increased, consistent with ongoing immune-mediated beta cell destruction. There was also a marked increase (more than approximately 100-fold) in the frequency of beta cell replication in all blocks examined.
CONCLUSIONS/INTERPRETATION: The present report provides direct evidence of attempted beta cell regeneration through the mechanism of beta cell replication in a case of newly diagnosed type 1 diabetes, and affirms that beta cell apoptosis is an important mechanism for beta cell loss in type 1 diabetes.
Health-e-Solutions comment: It has been widely believed that beta cells cannot regenerate. This single-patient study would indicate otherwise – at least in a person with newly-diagnosed type 1 diabetes. Many questions remain to be answered, but we would love to see a method of #CuringType1Diabetes that used natural means to stimulate beta cell regeneration and stop the autoimmune attack.
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Meier JJ, Lin JC, Butler AE, Galasso R, Martinez DS, Butler PC (2006) direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 49:1838-1844. [Diabetologia. 2006]