Beta Cell Regeneration Happens


HeConnection-Cure-Beta Cell RegenerationAbstract

AIMS/HYPOTHESIS: We investigated whether there was evidence of attempted beta cell regeneration in the pancreas obtained from an 89 year old patient with recent-onset type 1 diabetes, and if so by what mechanism this occurred.

SUBJECTS, MATERIALS AND METHODS: We examined pancreas tissue from a lean 89-year-old patient (BMI 18.0 kg/m(2)) with recent-onset type 1 diabetes who had had a distal pancreatectomy to remove a low-grade pancreatic intraepithelial neoplasia.

RESULTS: In the tumor-free tissue, the fractional beta cell area was about one-third of that in non-diabetic humans. CD3-positive T lymphocytes and macrophages had infiltrated the majority of the islets. Subclassification of the T cell population revealed a predominance of CD8-positive cells over CD4-positive cells. Beta cell apoptosis was greatly increased, consistent with ongoing immune-mediated beta cell destruction. There was also a marked increase (more than approximately 100-fold) in the frequency of beta cell replication in all blocks examined.

CONCLUSIONS/INTERPRETATION: The present report provides direct evidence of attempted beta cell regeneration through the mechanism of beta cell replication in a case of newly diagnosed type 1 diabetes, and affirms that beta cell apoptosis is an important mechanism for beta cell loss in type 1 diabetes.

Health-e-Solutions comment: It has been widely believed that beta cells cannot regenerate. This single-patient study would indicate otherwise – at least in a person with newly-diagnosed type 1 diabetes. Many questions remain to be answered, but we would love to see a method of #CuringType1Diabetes that used natural means to stimulate beta cell regeneration and stop the autoimmune attack.

HeS-lifestyle-Solutions-Road-Beta Cell RegenerationOur recipe e-books, workshops and home study course will teach you how to transform your lifestyle in a #PracticalLivableSustainable way for better living. You will enjoy a natural, innovative way to help master type1 diabetes and type 2 diabetes with healthy, natural, whole, #VeryLowGlycemic, low #InsulinDemand foods. There is strong evidence that better blood sugar control – without the roller-coaster ride of highs and lows – results in better health outcomes and fewer complications in the years ahead.

Meier JJ, Lin JC, Butler AE, Galasso R, Martinez DS, Butler PC (2006) direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 49:1838-1844. [Diabetologia. 2006]