Binge Drinking Increases Type 2 Diabetes Risk

(Source)

HeConnection-Cause-Binge Drinking Increases Type 2 Diabetes RiskBinge Drinking Increases Type 2 Diabetes Risk. Binge drinking causes insulin resistance, which increases the risk of Type 2 diabetes, according to the results of an animal study led by researchers at the Diabetes Obesity and Metabolism Institute at the Icahn School of Medicine at Mount Sinai. The authors further discovered that alcohol disrupts insulin-receptor signaling by causing inflammation in the hypothalamus area of the brain.

“Insulin resistance has emerged as a key metabolic defect leading to Type 2 diabetes and coronary artery disease (CAD),” said Christoph Buettner, MD, PhD, senior author of the study and Associate Professor of Medicine (Endocrinology, Diabetes and Bone Disease). “Someone who regularly binge drinks even once a week, over many years, may remain in an insulin resistant state for an extended period of time, potentially years,” said Dr. Buettner.

Rat Study

In this study, researchers treated rats with alcohol for three consecutive days to simulate human binge drinking. A control group received the same amount of calories. Once alcohol was no longer detectable in blood, glucose metabolism was studied through either glucose-tolerance tests or through controlled-insulin infusions. The rats treated with alcohol were found to have higher concentrations of plasma insulin than the control group, suggesting that insulin resistance may have been the cause of the impaired glucose tolerance.

High plasma insulin levels (hyperglycemia) are a major component of the metabolic syndrome, a group of risk factors that occur together and increase the risk for Type 2 diabetes, coronary artery disease, and stroke.

“Previously it was unclear whether binge drinking was associated with an increased risk for diabetes, since a person who binge drinks may also tend to binge eat, or at least eat too much. Our data show for the first time that binge drinking induces insulin resistance directly and can occur independent of differences in caloric intake,” said Claudia Lindtner, MD, first author of the study and an Associate Researcher of Medicine, Endocrinology, Diabetes and Bone Disease at the Icahn School of Medicine.

Health-e-Solutions comment

This is only a rat study, so we do not want to make too much of this until the same can be shown in humans (They may not have much trouble finding volunteers for that study). However, if we remember that alcohol is toxic to the body, it stands to reason that ingesting it could very easily disrupt metabolism for a period of time. The body is quite capable of detoxing itself, but repeated intoxication takes a toll on that capability over time. Alcohol consumption is not part of optimal health with the Health-e-Solutions lifestyle, so it should be weighed carefully if the benefits outweigh the health risks.

HeS-Control-Diabetes-lifestyle-Binge Drinking Increases Type 2 Diabetes RiskThe Health-e-Solutions products, services, tools and resources we provide for mastery of diabetes in the healthiest way possible are all designed to help you continue the learning process and shorten your learning curve with focus. Knowing you never arrive, but always continue to learn for mastery can help remove disappointment and replace it with excitement about what you will learn next! Your dreams, vision, ideals and standards

Journal Reference: C. Lindtner, T. Scherer, E. Zielinski, N. Filatova, M. Fasshauer, N. K. Tonks, M. Puchowicz, C. Buettner. Binge Drinking Induces Whole-Body Insulin Resistance by Impairing Hypothalamic Insulin ActionScience Translational Medicine, 2013; 5 (170): 170ra14 DOI:10.1126/scitranslmed.3005123