BPA Produces MBP Multiple Health Threats
BPA Produces MBP Multiple Health Threats – Bisphenol A or BPA is a synthetic chemical widely used in the making of plastic products ranging from bottles and food can linings to toys and water supply lines. When these plastics degrade, BPA is released into the environment and routinely ingested.
New research, however, from the University of California, San Diego School of Medicine suggests it is the metabolic changes that take place once BPA is broken down inside the body that pose the greater health threat.
More than 90 percent of all Americans are believed to carry varying levels of BPA exposure.
In recent years, numerous studies have reported alarming associations between BPA exposure and myriad adverse health and development effects, from cancer and neurological disorders to physiological defects and, perhaps, a cause of childhood obesity.
Of particular concern is that BPA exposure is correlated with disruption of estrogen signaling. The chemical’s molecular structure is similar to that of estradiol, one of the human body’s three main estrogens, suggesting that BPA binds to estrogen receptors. The estrogen receptor is designed to grab and hold estradiol and related estrogens. Disparate chemicals, however, can share some structures found in estrogens, enabling them to bind to the estrogen receptor. When that happens, problems can occur.
In binding to the estrogen receptor, BPA can disrupt the body’s endocrine or hormone system, with consequences especially worrisome for fetuses, infants and young children. Earlier this year, the U.S. Food and Drug Administration banned BPA in baby bottles and sippy-cups. Its use is more broadly banned elsewhere in the world.
In new research published in the journal PLOS ONE, two scientists at UC San Diego School of Medicine say three-dimensional modeling suggests a metabolite of BPA — a molecule produced when BPA is metabolized or broken down by the body — actually binds to the estrogen receptor much more strongly than BPA itself. The finding could point the way to development of a new class of drugs designed to specifically inhibit excessive estrogen activity linked to disease.
In 2004, Shin’ichi Yoshihara, PhD, and colleagues at Hiroshima International University, discovered that a compound, dubbed MBP, was produced when BPA was metabolized. MBP has a 100-fold to 1,000-fold stronger bond to the estrogen receptor than BPA. However, the structural basis for MBP’s high affinity for the estrogen receptor was not investigated further.
In their PLOS ONE study, Baker and Chandsawangbhuwana revived Yoshihara’s research by creating three-dimensional, molecular models of MBP and BPA in the estrogen receptor and matching it against the crystal structure of estradiol in the estrogen receptor. They found that MBP’s longer structure allows both ends of the chemical to interact with the estrogen receptor in a way similar to estradiol. The shorter BPA molecule contacts the receptor at just one end, resulting in a weaker connection, providing an explanation for BPA’s lower affinity for the estrogen receptor.
“In other words, MPB is basically grabbing onto the estrogen receptor with two hands compared to just one hand for BPA,” said Baker. “Two contact points makes a much stronger connection.”
“One could use MBP, which has a novel structure, as a template to develop a new class of chemicals that could bind to the estrogen receptor with high affinity,” Baker said. “The goal would be to have these chemicals inhibit the action of estradiol instead of activating the estrogen response. These chemicals could control unwanted growth of estrogen-dependent tumors.”
The environmental triggers and potentiators that contribute to the development and progression of diabetes and other chronic diseases should be taken seriously. Reducing exposure to such environmental factors may go a long way in putting the body in a position of strength for sustainable health. The Roman Diet and Health-e-Solutions lifestyle is all about minimizing controllable risk factors and increasing health and wellness through dietary and lifestyle changes. These are fast becoming of great importance in the management of chronic diseases such as type 1 and type 2 diabetes.
Our environment, internal and external, indoors and outdoors, has reached a point of inescapable concern. Taking healthy measures to minimize your exposure and keep your body’s detoxification systems functioning optimally can be of great benefit to long term health and #BloodSugarControl.
In our downloadable, printable special report on the Environment, Diabetes and Health, we present evidence that demands action, and we give you the tools to take action to #MasterDiabetesNaturally. This is one of the five pillars in the Health-e-Solutions lifestyle that supports thriving health and better BloodSugarControl.