Diet Increases Blood Factors with Anti-Diabetes Properties
A calorie-restricted diet increases blood factors in rats that can modify energy-producing mitochondria within the insulin-producing cells that regulate blood sugar levels, new research shows. This has a positive impact on glucose-stimulated insulin secretion and protects cells from fatty acid and glucose toxicity.
The findings suggest that insulin-producing cells’ mitochondria may be altered by signals independent of the body’s fuel levels and may represent a useful therapeutic target in type 2 diabetes. Additionally, identifying these blood factors may open even more targetable interventions against the disease.
“Our findings support the concept that the impact of diet on insulin secreting cells is mediated by signals traveling through the blood rather than the nutrients and metabolites themselves. These signals may be generated elsewhere in other organs such as fat tissue, liver, brain or even the immune cells,” said Dr. Orian Shirihai, co-author of The FEBS Journal study.
“Our findings also suggest that at least in part the beneficial effect of reducing caloric intake is mediated by the appearance of a protective signal rather than the elimination of a harmful one. This study describes an experimental system through which such signals can be identified and characterized with the hope that in the future it can potentially be mimicked using a small compound.”
Health-e-Solutions comment: Beta cells quickly adjust insulin secretion to the nutrients carried by the blood, acting as fuel sensors. However, most studies in beta-cell response to nutrients do not distinguish between fuel levels and signaling components present in the circulation. This study does that, focusing on the difference in blood glucose regulation between rats fed regular chow and those fed calorie-restricted diets. Not only does the nutrient content of food impact blood sugar control, other factors in the blood do the same, and these factors are increased – at least in rats – by calorie restriction.
The researchers concluded, “Overall, our results provide evidence that non-nutrient factors carried by sera have a major impact on beta-cell mitochondrial adaptations to changes in metabolism.”
Other research has demonstrated that ketogenic diets and intermittent fasting can produce effects similar to calorie restriction. #TheRomanDIet is ketogenic without limiting calories. This is why we think it is a good approach for people with diabetes. This research suggests that not only the #VeryLowGlycemic and low #InsulinDemand poperties of the Roman Diet are beneficial to blood sugar control, but the similarities to calorie restriction also benefit blood sugar control – without restricting calories.
The core of the Health-e-Solutions lifestyle uses food as a means by which to #MasterDiabetesNaturally, the healthiest way possible. With the understanding that there is much more to be explored, we delve into a number of #NaturalDiabetesTreatments we have researched and found to be sufficiently safe and effective. In this downloadable, printable e-publication called More Natural Remedies, we stay “close to home,” as it were, as we discuss additional treatment topics primarily having to do with food as medicine. They offer innovative, practical, natural remedies to improve health and #ControlDiabetes.
Journal Reference: Fernanda M. Cerqueira, Bruno Chausse, Boris M. Baranovski, Marc Liesa, Eli C. Lewis, Orian S. Shirihai, Alicia J. Kowaltowski. Diluted Sera From Calorie Restricted Animals Promote Mitochondrial Beta-Cell Adaptations and Protect Against Glucolipotoxicity.FEBS Journal, 2016; DOI: 10.1111/febs.13632