Drug Combo Fails Reversing Type 1 Diabetes Autoimmunity
Drug Combo Fails Reversing Type 1 Diabetes Autoimmunity – Results from a novel experimental therapy for Type 1 diabetes that boosts parts of the healthy immune system are reported in the scientific journal Diabetes. The trial was led by Carla Greenbaum, MD, Diabetes Research Program director at Benaroya Research Institute at Virginia Mason (BRI), and sponsored by the Immune Tolerance Network (ITN), a clinical trial network funded by the National Institutes of Health. The trial took a unique two-pronged approach to treating Type 1 diabetes in newly diagnosed participants. Two drugs were administered in combination. One drug interferes with the immune response that causes Type 1 diabetes while a second drug simultaneously boosted the part of the immune response that usually regulates overactive immune cells.
In Type 1 diabetes the body’s immune system attacks and destroys the insulin-producing cells in the pancreas, called beta cells. However, at the time of diagnosis with Type 1 diabetes, a small number of beta cells may remain active in many individuals.
Since even small amounts of natural insulin production can decrease the long-term effects of diabetes, therapies that attempt to rescue these remaining cells are badly needed.
In the clinical research trial, the combination of the two drugs Proleukin (IL-2) and Rapamune (sirolimus) were administered to see whether the drugs would affect the immune system to halt the autoimmune destruction of the remaining beta cells. The authors of the study describe successful boosting of regulatory components of the immune system in all nine subjects treated in the trial. However, other elements of the immune system also were expanded that were not anticipated. The temporary impairment of beta cell function led the authors to conclude that this drug combination was not having the desired overall effect. Monitoring of the insulin production in the nine subjects indicated that the beta cell preservation goal was not achieved, and the study was therefore stopped. “This study result has been extremely important to scientists looking for ways to stop the immune attack,” says Dr. Greenbaum. “Our aim would be to harness the good effects of this therapy while preventing the bad effects.” Participants who haven’t yet completed the study will continue to be followed.
“The clinical and mechanistic findings from this study can help guide future treatments that boost good immunity,” says Gerald Nepom, MD, PhD, Director of ITN. “This was an important clinical trial that will improve the design of subsequent trials to rescue beta cells in Type 1 diabetes.
This is a frequent problem with drug interventions: “other elements of the immune system also were expanded that were not anticipated.” We cannot anticipate all of the interactions that may occur in the body when we interfere with its natural mechanisms of action. Some interactions may not reveal themselves until years down the road. This is why we prefer the natural treatment and management of our two boys’ type 1 diabetes via the Roman Diet and Health-e-Solutions lifestyle. As much as possible we want to rely on diet and lifestyle changes to provide optimal blood glucose control and strong, healthy bodies. We are thankful for safe medications when they are needed, but we prefer diet and lifestyle changes to be the first treatment option and drugs to be supportive instead of being the primary intervention.
Until #CuringType1Diabetes is a reality within our reach, put your body in a position of strength to #MasterDiabetes the healthiest way possible. Lifestyle innovations as a priority over drug therapies may be the solution. Poor health feeds poor health in a vicious cycle, or negative feedback loop that is increasingly difficult to break the longer it continues. Promoting, supporting and creating health set in motion a positive feedback loop instead.
Get tools and solutions to help minimize consequences and maximize benefits for nutrition, environment, exercise, sleep and stress management. These five health components make up the five pillars of health and nutrition in the Health-e-Solutions lifestyle. We’ll teach you how to improve each of these areas to help you Master Diabetes the healthiest way possible.