(Abstract)

HeConnection-CauseAIMS/HYPOTHESIS:

Evidence for the role of infant feeding in the development of beta cell autoimmunity is inconsistent. We set out to study the effects of breastfeeding and of age at introduction of supplementary foods on the development of beta cell autoimmunity.

SUBJECTS AND METHODS:

A prospective birth cohort of 3,565 infants with HLA-DQB1-conferred susceptibility to type 1 diabetes was recruited between 1996 and 2001 from two university hospital areas in Finland. Blood samples were collected at 3- to 12-month intervals to measure antibodies against islet cells, insulin, glutamate dehydroxylase and islet antigen 2. The families kept a record on the age at introduction of new foods, and for each visit completed a structured dietary questionnaire. The endpoint was repeated positivity for islet cell antibodies together with at least one of the other three antibodies.

RESULTS:

The overall or exclusive duration of breastfeeding was not associated with the risk of developing the endpoint. An early age at introduction of fruits and berries (< or =4 months) was related to increased risk of developing positivity for the endpoint. Also, introducing roots between 3 and 3.9 months was related to increased risk of the endpoint. These associations were independent of several putative socio-demographic and perinatal confounding factors.

CONCLUSIONS/INTERPRETATION:

Our findings suggest that an early age at introduction of fruits and berries and roots associates independently with beta cell autoimmunity, contradicting earlier findings from smaller birth cohort studies.

Health-e-Solutions comment: It is not clear from this abstract which fruits, berries and roots were eaten that associated positively with beta cell autoimmunity development. Most important seems to be the timing of the introduction of these foods. Early introduction of foods has been shown in other studies to cause antibody positivity as well. The Health-e-Solutions lifestyle minimizes all foods in these categories that are not very low-glycemic and alkalizing. If the results of this study are corroborated with other research, then the evidenc will likely support the Health-e-Solutions lifestyle approach to managing diabetes.

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