GABA Works on Human Beta Cells Transplanted into Mice, Curing Type 1 Diabetes

(Source)

HeConnection-Cure-GABA Works on Human Beta CellsGABA, a chemical produced in the pancreas has been shown previously to prevent and even reverse Type 1 diabetes in mice. New research has found that GABA Works on Human Beta Cells Transplanted into Mice as well, #CuringType1Diabetes.

GABA, or gamma-aminobutryic acid, is an amino acid produced by the same beta cells that make and secrete insulin.

Drs. Gerald Prud’homme and Qinghua Wang of the Keenan Research Centre for Biomedical Sciences of St. Michael’s Hospital published a paper in 2011 showing for the first time that GABA injections not only prevented Type 1 diabetes in mice, but even reversed the disease.

A new paper published in Diabetes shows GABA does the same thing in mice who have been injected with human pancreatic cells.

Type 1 diabetes, formerly known as juvenile diabetes, is characterized by the immune system’s destruction of the beta cells in the pancreas. As a result, the body makes little or no insulin. The only conventional treatment for Type 1 diabetes is insulin injection, but insulin is not a cure as it does not prevent or reverse the loss of beta cells.

Drs. Prud’homme and Wang also found that GABA vastly improved the survival rate of pancreatic cells when they were being transplanted into mice. About 70 per cent of pancreatic cells die between the time the organ is harvested and transplanted. The researchers said their finding could lead to future research specifically related to pancreatic transplants.

GABA has been known for decades to be a key neurotransmitter in the brain, a chemical that nerve cells use to communicate with each other, but its role in the pancreas was unknown until the 2011 paper by Drs. Prud’homme and Wang.

GABA and related therapies would have to be tested in human clinical trials, a process that could take several years, the researchers said, noting that many treatments that work in mice do not always translate into effective human therapies

Health-e-Solutions comment: I like the fact that this is using something that is produced naturally in the body. This will be a very significant therapy for treating type 1 diabetes if it proves to be as effective in human trials. This study brings us one step closer to that goal. Of course we’d want to see that it is very safe as well. Mouse studies are notorious for finding “cure” therapies to treat type 1 diabetes, but not turning out so well with human trials.

Food Sources of GABA

GABA can produce a calming and even sleep-inducing effect on your body by bonding with receptors in your brain and slowing the rate your nerves fire at.

There is very little research available regarding consuming GABA in your diet. The foods highest in GABA content are oily fish, such as salmon and mackerel, especially mackerel. GABA is not a required nutrient because your body naturally produces it in the amounts you need.

Dr. Eric Braverman, an authority on brain chemistry and author of the book, The Edge Effect: Achieve Total Health and Longevity with the Balanced Brain Advantage, explains, “The more GABA-producing foods you eat, the more you will be able to create.”  Dr. Braverman lists the following foods, which don’t contain GABA but they contain glutamate or glutamic acid, which forms glutamine in your body and is a precursor to GABA.  The list is basically in descending order of how much you get from a typical portion [the items in bold fit best with the Health-e-Solutions lifestyle]:

  • Almonds
  • Tree nuts
  • Bananas
  • Beef Liver
  • Broccoli
  • Brown Rice
  • Halibut
  • Lentils
  • Oats, whole grain
  • Oranges, lemons, limes, other citrus fruit
  • Rice bran
  • Spinach
  • Walnuts
  • Whole wheat, whole grains.

Other nutrients can affect how well your body synthesizes GABA:

  • The primary form of vitamin B-6 that you consume in your diet functions as a precursor to many neurotransmitters, including GABA. Take in this nutrient daily in foods from the list above.
  • L-Glutamine – This is a fantastic amino acid and is the most abundant in the muscle and blood plasma. It makes up an astounding 61% of your muscle tissue.  It’s one of the most studied amino acids and it has numerous benefits, but for our purposes here it will increase your GABA levels.

HeS-Manage-Diabetes-lifestyle-GABA Works on Human Beta Cells You may be dissatisfied with the typical diabetes plan of care, which puts a priority on insulin and drug therapies over lifestyle. We believe this order must be reversed; that a healthier lifestyle should take precedence over drug therapies. This natural, innovative approach may reduce or eliminate your dependence on medications. It may set you on a path to better health and vitality. Through our recipe e-books workshops, home study course and other products and services we will teach you how to transform your lifestyle in a #PracticalLivableSustainable way for optimal #BloodSugarControl and better living..

Journal Reference: I. Purwana, J. Zheng, X. Li, M. Deurloo, D. O. Son, Z. Zhang, C. Liang, E. Shen, A. Tadkase, Z.-P. Feng, Y. Li, C. Hasilo, S. Paraskevas, R. Bortell, D. L. Greiner, M. Atkinson, G. J. Prud’homme, Q. Wang. GABA Promotes Human  -Cell Proliferation and Modulates Glucose HomeostasisDiabetes, 2014; 63 (12): 4197 DOI: 10.2337/db14-0153

References:

  1. http://www.ratracetrap.com/the-rat-race-trap/your-brain-on-food-and-supplements-%E2%80%93-gaba.html
  2. http://www.integrativepsychiatry.net/natural_gaba.html
  3. http://www.livestrong.com/article/520305-food-sources-of-gaba/
  4. http://www.suite101.com/content/gaba-foods-natural-anti-anxiety-nutrition-a82345