Good Intestinal Bacteria May Prevent Type 1 Diabetes
Good Intestinal Bacteria May Prevent Type 1 Diabetes – All humans have enormous numbers of bacteria and other micro-organisms in the lower intestine. In fact our bodies contain about ten times more bacteria than the number of our own cells and these tiny passengers are extremely important for our health. They help us digest our food and provide us with energy and vitamins. These ‘friendly’ commensal bacteria in the intestine help to stop the ‘bad guys’ that cause infections such as Salmonella from taking hold. Even the biochemical reactions that build up and maintain our bodies come from our intestinal bacteria as well as our own cells.
Pretty important that we get along with these little bacterial friends… definitely. But as in all beautiful relationships, things can sometimes turn sour. If the bacteria in the intestine become unbalanced, inflammation and damage can occur at many different locations in the body. The best known of these is the intestine itself: the wrong intestinal bacteria can trigger Crohn’s disease and ulcerative colitis. The liver also becomes damaged when intestinal bacteria are unbalanced.
Research groups led by Professor Jayne Danska at the Sick Children’s Hospital of the University of Toronto and Professor Andrew Macpherson in the Clinic for Visceral Surgery and Medicine at the Inselspital and the University of Bern have now shown that the influence of the intestinal bacteria extends even deeper inside the body to influence the likelihood of getting type 1 diabetes. In children and young people, diabetes is caused by the immune cells of the body damaging the special cells in the pancreas that produce the hormone insulin. By chance, 30 years ago, before the development of genetic engineering techniques, Japanese investigators noticed that a strain of NOD laboratory mice tended to get type 1 diabetes. These mice (also by chance) have many of the same genes that make some humans susceptible to the disease. With the help of the special facilities of the University of Bern and in Canada, these teams have been able to show that the intestinal bacteria, especially in male mice, can produce biochemicals and hormones that stop type 1 diabetes developing.
Diabetes in young people is becoming more and more frequent, and doctors even talk about a diabetes epidemic. This increase in type 1 diabetes has happened over the last 40 years as our homes and environment have become cleaner and more hygienic. At the moment, once a child has type 1 diabetes, he or she requires life-long treatment.
“We hope that our new understanding of how intestinal bacteria may protect susceptible children from developing type 1 diabetes, will allow us to start to develop new treatments to stop children getting the disease,” says Andrew Macpherson of the University Bern.
We do too! We also believe that gut health is critical to diabetes control, possibly even to a cure. In the future, it may well be shown that epigenetics is playing a role in the diabetes epidemic. It is already known that we pass on to our children not only our genes, but also how our genes are expressed. It is also known that lifestyle, environment and diet can change genetic expression. We want to influence genetic expression positively through a healthier, safer, less toxic lifestyle and environment.
Until we have a #Type1DiabetesCure, it is our opinion that to #MasterDiabetes in the healthiest way possible through lifestyle innovations as a priority over drug therapies is vital. It is important for optimal #BloodSugarControl today, but it can help put your body in a position of strength for tomorrow – for that day when a #CuringType1Diabetes is a reality. Our Roman Diet Diabetes recipe e-books, workshops and home study course will teach you how to transform your lifestyle in a #PracticalLivableSustainable way for better living.
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Journal Reference: J. G. M. Markle, D. N. Frank, S. Mortin-Toth, C. E. Robertson, L. M. Feazel, U. Rolle-Kampczyk, M. von Bergen, K. D. McCoy, A. J. Macpherson, J. S. Danska.Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity.Science, 2013; DOI: 10.1126/science.1233521