Grape Seed Extract Beats Diabetes Drug


HeConnection-Vitamins-Minerals-Supplements-Grape Seed Extract Beats Diabetes DrugGrape Seed Extract Beats Diabetes Drug. A new study published in the Journal of Cell Communication and Signaling compared the effects of a grape seed extract (GSP) to the diabetes drug metformin (MET) in rats fed a high fat, high fructose diet (HFFD) designed to provoke insulin resistance.

Titled, “Grape seed proanthocyanidins and metformin act by different mechanisms to promote insulin signaling in rats fed high calorie diet,” Indian researchers discovered that both substances reduced elevated blood glucose (hyperglycemia) and elevated blood insulin (hyperinsulinemia), while improving the following diet-altered parameters: glycolysis, tyrosine phosphorylation of IR-β and IRS-1, IRS-1-PI3K association and Akt activation.[1]

Furthermore, adverse changes induced by the HFFD, such as the activation of tumor necrosis factor-α, interleukin-6, leptin and suppression of cytokine signaling-3 and reduction in adiponectin, were reversed by GSP more effectively than by MET.

Proanthocyanidins are a type of secondary plant metabolites known as flavonoids found in many plants, but are particularly concentrated in cocoa beans, cinnamon, grape seeds and skin, and maritime pine bark (pycnogenol). Proanthrocyanidins are known primarily through their antioxidant properties.

Metformin, on the other hand, is an oral antidiabetic drug in the biguanide class, and is used as the first-line drug for the treatment of type 2 diabetes. The original inspiration for the biguanide class was the discovery, in the 1920s, of guanidine compounds within the herb French lilac (Galega officinalis), long used to treat diabetes in traditional medicine. Metformin, however, is an entirely synthetic compound, whose exact mechanisms of action are unknown. What is known is that like other antidiabetic drugs (e.g. Avandia) metformin is cardiotoxic and has been linked to increased cardiac mortality in a number of studies. Proanthrocyanidins, and grape seed extract in particular, have been extensively researched to have protective and therapeutic properties on the cardiovascular system.

The weight of evidence suggests that grape seed proanthrocyanins hold great promise as a metformin alternative and/or anti-diabetic agent. Unfortunately, the law forbids the medicinal use of natural substances, and lacking the $800 million plus required on average to fund the clinical trials necessary to file for FDA drug approval, health consumers are left almost entirely without guidance from conventional medical practitioners who lose their FDA-underwritten liability shield when they deviate from the drug-based standard of care.

A deeper level of self-care focuses on identifying the environmental, dietary and lifestyle-based causes of blood sugar and insulin disorders, and altering them so that a magical “pharmaceutical” or “nutraceutical” bullet isn’t so necessary.

Health-e-Solutions comment

We use cold-pressed, extra-virgin grape seed oil as one of our cooking oils in the Health-e-Solutions lifestyle. It is good to see studies revealing the anti-diabetic, blood sugar lowering qualities of the flavonoids in this remarkable oil and seed extract.

HeS-lifestyle-Solutions-Road-Grape Seed Extract Beats Diabetes DrugOur recipe e-books, workshops and home study course will teach you how to transform your lifestyle in a practical, livable way for long term sustainability and better living. You will enjoy a natural, innovative way to help control type 1 and type 2 diabetes with healthy, natural, whole, very low-glycemic foods. There’s strong evidence that better blood sugar control – without the roller-coaster ride of highs and lows – results in better health outcomes and fewer complications in the years ahead.


  1. Baskaran Yogalakshmi, Saravanan Bhuvaneswari, S Sreeja, Carani Venkatraman Anuradha. Grape seed proanthocyanidins and metformin act by different mechanisms to promote insulin signaling in rats fed high calorie diet.J Cell Commun Signal. 2013 Sep 12. Epub 2013 Sep 12. PMID: 24026800