Help Preserving Type 1 Diabetes Pancreas Cells

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HeConnection-Treatment-Prevention-Help Preserving Type 1 Diabetes Pancreas CellsHelp Preserving Type 1 Diabetes Pancreas Cells. Used early after diagnosis, drug appears to have long-lasting effects, study reports.

Taking two 12-week courses of alefacept — a drug already approved to treat the skin condition psoriasis — may help people with newly diagnosed type 1 diabetes preserve some function in the beta cells in the pancreas, a new study suggests.

People taking the drug needed about 25 percent less insulin, and they had about half the rate of major low blood sugar episodes (hypoglycemia) compared to those who took a placebo, the study revealed.

“This is the first time that documented rates of hypoglycemia — using standardized home glucometers in all patients — have shown a reduction in major hypoglycemia events following an immune intervention in new-onset [type 1 diabetes] patients,” lead researcher Dr. Mario Ehlers, of the Immune Tolerance Network, said in a network news release.

“This is important because frequent hypoglycemia is a common and serious complication in this disease,” Ehlers added.

Type 1 diabetes is an autoimmune disease that causes the body’s immune system to mistakenly attack the insulin-producing beta cells in the pancreas. Specifically, certain T-cells in the immune system lead the attack. When enough beta cells have been destroyed, a person can no longer produce enough insulin. Insulin is necessary to help the sugars in foods get into the body’s cells to be used as fuel.

When used early after diagnosis, alefacept may interfere with the action of the destructive T-cells. And the drug appears to do this without affecting another type of T-cell that is protective, the researchers noted.

The Trial

The current clinical trial — the second of three required for approval — included 49 people between the ages of 12 and 35 who were newly diagnosed with type 1 diabetes. Patients were randomly selected to receive the drug or a placebo. Thirty-three people were given the drug for two 12-week courses, with a 12-week gap in between the courses.

Over two years of follow-up, the group that received the drug had a lower decline in a marker of beta cell function known as C-peptide. Moreover, nine out of 30 patients evaluated for C-peptide function showed no decline in C-peptide production, compared to just one of 12 people evaluated in the placebo group. Preservation of C-peptide lasted as long as 15 months after treatment stopped, Ehlers noted.

“Achieving long-term benefit following a short course of therapy is a challenging goal,” Dr. Gerald Nepom, director of the Immune Tolerance Network, said in the news release.

“Detailed analysis of the T-cell types present in the blood of those who responded to the treatment will help us identify the best way to improve this type of immune therapy for patients with type 1 diabetes and potentially other autoimmune diseases,” he added.

The study results were published in the Journal of Clinical Investigation.

Health-e-Solutions comment

Using 25% less insulin can b accomplished by changing your diet. What is more intriguing is beta cell preservation. It remains to be seen how long this might last. We still maintain that lifestyle change is a fundamental component to mastering diabetes in the healthiest way possible, and to reversing the course of the prevalence of all chronic diseases.

Health-e-Solutions-Outlook-Wow-Help Preserving Type 1 Diabetes Pancreas CellsUntil we have a cure for type 1 diabetes, it is our opinion that mastering this disease in the healthiest way possible through lifestyle innovations as a priority over drug therapies is vital. It is important for optimal blood sugar control today, but it can help put your body in a position of strength for tomorrow – for that day when the cure for type 1 diabetes may be found.

Our recipe e-books, workshops and home study course will teach you how to transform your lifestyle in a practical, livable way for long term sustainability and better living. Our support services can make the difference between success and failure during your transformation. And our advanced resources will take you deeper into practical application and underlying research. Let us help you shorten the learning curve to successful lifestyle transformation by setting you on the path toward optimal blood sugar control and better living.

SOURCE: Immune Tolerance Network, news release, July 20, 2015