Higher GI Foods May Cause Type 1 Diabetes Progression
CONTEXT: Dietary factors may trigger or exacerbate the autoimmune disease process.
OBJECTIVE: Our objective was to examine dietary glycemic index (GI) and glycemic load (GL) for association with islet autoimmunity (IA) development, and progression from IA to type 1 diabetes.
DESIGN: The Diabetes Autoimmunity Study in the Young follows children at increased genetic type 1 diabetes risk. Diet is collected prospectively via a parent-reported food frequency questionnaire.
SETTING: This was an observational study of children in the Denver area.
PATIENTS: A total of 1776 Diabetes Autoimmunity Study in the Young children younger than 11.5 yr was included in the study.
MAIN OUTCOME MEASURES: IA, defined as the presence of autoantibodies to insulin, glutamic acid decarboxylase, or protein tyrosine phosphatase at two consecutive visits, or the presence of autoantibodies at one visit and diabetic on the next consecutive visit was determined. Type 1 diabetes was diagnosed by a physician. A total of 89 subjects developed IA, and 17 subsequently developed type 1 diabetes during follow-up. Our hypothesis was formulated after data collection.
RESULTS: GI and GL were not associated with IA development. More rapid progression to type 1 diabetes in children with IA was associated with higher dietary GI and marginally associated with GL at the first IA-positive visit.
CONCLUSIONS: Higher dietary GI and GL are not associated with IA development, but higher GI is associated with more rapid progression to type 1 diabetes in children with IA, perhaps due to increased demand on the beta-cell to release insulin. Further study is needed to confirm this finding and identify the underlying biological mechanism.
Health-e-Solutions comment: #TheRomanDiet is #VeryLowGlycemic (GI) and very low in glycemic load (GL), but also low in #InsulinDemand, anti-inflammatory, high in nutrient-dense and alkalizing, gluten- and dairy-free, whole foods. We do everything we can to slow the progression of type 1 diabetes by keeping demand on the beta cells to a minimum, which has worked amazingly well for us. For some people following this lifestyle, disease progression seems to stop, while the majority may require a minimal amount of insulin to keep excellent blood sugar control. Until we have a #Type1DiabetesCure, we strive to achieve the healthiest way possible to #MasterDiabetes
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Modern, industrialized food modification, farming, and processing have contributed to the unprecedented rise in chronic lifestyle and autoimmune diseases, as this research suggests. A fundamental problem in diabetes is the body’s inability to metabolize glucose properly. This in-depth report provides information, evidence and data with which to understand the methodology behind the Health-e-Solutions lifestyle. It provides you with insight into why we think it works so well for #BloodSugarControl and better living.