Washington State University researchers have lengthened their list of environmental toxicants; Jet Fuel, Plastics – that can negatively affect as many as three generations of an exposed animal’s offspring.
Writing in the online journal PLOS ONE, scientists led by molecular biologist Michael Skinner document reproductive disease and obesity in the descendants of rats exposed to the plasticizer bisephenol-A, or BPA, as well DEHP and DBP, plastic compounds known as phthalates.
In a separate article in the journal Reproductive Toxicology, they report the first observation of cross-generation disease from a widely used hydrocarbon mixture the military refers to as JP8.
Significant Increases” in Disease and Abnormalities
Both studies are the first of their kind to see obesity stemming from the process of “epigenetic trans-generational inheritance.” While the animals are inheriting traits conveyed by their parents’ DNA sequences, they are also having epigenetic inheritance with some genes turned on and off. Skinner’s lab in the past year has documented these epigenetic effects from a host of environmental toxicants, including plastics, pesticides, fungicide, dioxin and hydrocarbons.
The recent PLOS ONE study found “significant increases” in disease and abnormalities in the first and third generations of both male and female descendants of animals exposed to plastics. The first generation, whose mother had been directly exposed during gestation, had increased kidney and prostate diseases. The third generation had pubertal abnormalities, testis disease, ovarian disease and obesity.
The study also identified nearly 200 epigenetic molecular markers for exposure and trans-generational disease. The markers could lead to the development of a diagnostic tool and new therapies.
The Reproductive Toxicology study exposed female rats to the hydrocarbon mixture as their fetuses’ gonads were developing. The first generation of offspring had increased kidney and prostate abnormalities and ovarian disease. The third generation had increased losses of primordial follicles, the precursors to eggs, polycystic ovarian disease and obesity.
The study, said Skinner, “provides additional support for the possibility that environmental toxicants can promote the epigenetic trans-generational inheritance of disease.”
“Your great-grandmother’s exposures during pregnancy may cause disease in you, while you had no exposure,” he said. “This is a non-genetic form of inheritance not involving DNA sequence, but environmental impacts on DNA chemical modifications. This is the first set of studies to show the epigenetic trans-generational inheritance of disease such as obesity, which suggests ancestral exposures may be a component of the disease development.”
Health-e-Solutions comment: The study of epigenetics provides fuel for us to transform our lifestyles away from the typical Western lifestyle toward a more health-sustaining way of living that may have impact well beyond our own health. We hope to impact the health of our children and their children as well!
Let us help you shorten the learning curve to successful lifestyle transformation by setting you on the path toward optimal blood sugar control and better living. Our Recipe e-Books provide innovative alternatives to the typical high-carb, low nutrition foods that wreak havoc on diabetes management but are standard fare for the typical western diet. Our Home Study Course teaches you how to implement the Health-e-Solutions lifestyle in a practical and livable way. We think this lifestyle can form the foundation for a natural way to better control all types of diabetes, putting the body in a position of strength for better living. All of our products and services are designed to help shorten your learning curve to achieve the greatest success in controlling blood sugars naturally and mastering diabetes in the healthiest way possible.
- Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna, Michael K. Skinner. Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations. PLoS ONE, 2013; 8 (1): e55387 DOI:1371/journal.pone.0055387
- Carlos Guerrero-Bosagna, Trevor R. Covert, Md. M. Haque, Matthew Settles, Eric E. Nilsson, Matthew D. Anway, Michael K. Skinner. Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers.Reproductive Toxicology, 2012; 34 (4): 694 DOI:1016/j.reprotox.2012.09.005