Lacking Certain Proteins Causes Type 1 Diabetes
Lacking Certain Proteins Causes Type 1 Diabetes – The absence of related protein molecules, Puma and Bin, prompts immune cells to turn against human organs they are meant to protect and cause type 1 diabetes and rheumatoid arthritis….
Daniel Gray and colleagues from the Walter and Eliza Hall Institute’s Molecular Genetics of Cancer division and the University of Ballarat, have discovered that this pair of protein molecules work together to kill so-called ‘self-reactive’ immune cells that are programmed to attack the body’s own organs.
Autoimmune diseases, such as type-1 diabetes, rheumatoid arthritis, inflammatory bowel disease and multiple sclerosis, develop when immune cells launch an attack on the body’s own cells, destroying important body organs or structures.
Puma and Bim are so-called ‘BH3-only’ proteins that make cells die by a process called apoptosis or self death. Defects in apoptosis proteins have been linked to many human diseases, including cancer and neurodegenerative disorders, according to an Eliza Hall statement.
Gray said one way the body protects itself against autoimmune disease is by forcing most self-reactive immune cells to die during their development. “If any self-reactive cells manage to reach maturity, the body normally has a second safeguard of switching these potentially dangerous cells into an inactive state, preventing them from causing autoimmune disease,” he said.
Gray is now collaborating with researchers who have identified human gene defects linked to the development of autoimmune conditions.
“We now know that self-reactive cell death is an important protection against autoimmunity,” Gray said. “The next stage of our work is to discover whether defects in the cell death process cooperate with other factors to cause human autoimmune disease.”
This represents another piece to the puzzle of how autoimmune diseases develop. Other research has pointed out the strong connection between gut health and autoimmune diseases, with celiac disease being directly linked to gluten sensitivity. It is very possible that most, if not all autoimmune diseases have food triggers that either cause or trigger in some way the autoimmune attack that leads to disease. The Roman Diet and Health-e-Solutions lifestyle endeavors to minimize as many possible “trigger” as can be controlled by diet and lifestyle changes.
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