Reducing HbA1c Reduces Death Risk
Reducing HbA1c Reduces Death Risk – Patients who had suboptimal glycemic control and reduced their HbA1c value by slightly less than 1% were 50% less likely to die within 5 years than were patients whose HbA1c did not improve….
At 5 years, all-cause mortality was 15% among the group with no improvement in HbA1c and 10% in the group with improved HbA1c in an observational study of 12,359 patients with poorly controlled type 2 diabetes at baseline. The patients were selected from the Swedish National Diabetes Registry and their outcomes were verified by the Swedish Cause of Death and Hospital Registries. None of the patients had any cardiovascular or coronary heart disease at baseline.
After adjusting for baseline risk factors and treatment changes during the study period, patients whose HbA1c decreased were half as likely to develop cardiovascular or coronary heart disease as were those whose levels increased. They were also 33% less likely to experience fatal cardiovascular disease and 41% less likely to die from any cause than were those in the poorly controlled group. All of these differences were statistically significant.
Dr. Eeg-Olofsson of the University of Gothenburg, Sweden stated that, “Patients with poorly controlled blood glucose clearly benefit” from gaining and improving glycemic control. “We must make an effort to identify patients who don’t respond to diabetes medications earlier.”
For the study, Dr. Eeg-Olofssson separated the patients into two groups: Those whose HbA1c decreased by at least 0.1% over the 5 years (6,841) and those whose HbA1c remained stable or increased by at least 0.1% (5,518).
At baseline, the patients averaged 62 years old, with mean disease duration of 9 years. Their average baseline HbA1c was 7.8%, and their mean body mass index was 30 kg/m2. Their mean blood pressure was 140/78 mmHg; 62% were taking antihypertensives and 46% were on lipid-lowering drugs.
After 5 years, mean HbA1c was 7% in the improved-control group (-0.8%) and 8.4% in the poorly controlled group (+0.7%), she said.
By then, 12% of the well-controlled group and 20% of the poorly controlled group had developed coronary heart disease. Cardiovascular disease was present in 17% of those in the well-controlled group and 30% of the poorly controlled group. Both these findings were statistically significant.
An HbA1c of 7% is not what I would consider well controlled. The normo-glycemic average is below 5%. That is what we strive to maintain with the Roman Diet and Health-e-Solutions lifestyle. Hyperglycemia is associated with many diseases, affecting every cell within the body. Microvascular damage has been shown to begin at the HbA1c of 5.6% and above. It would make sense to work towards achieving and maintain blood sugars below that level.
Mapping, monitoring and measuring are a continuous cycle when living with diabetes. You begin with a certain course of treatment in mind, which you mapped out with the help of your medical professional. You monitor your progress and measure it against your goals. Upon evaluation, you may find a new course must be corrected to compensate for successes and challenges.
Evaluating progress and results of the Health-e-Solutions lifestyle is essential to #MasterDiabetes in the healthiest way possible. This downloadable e-publication equips you with the key evaluation tools you need, along with some of the research behind them, to determine where you want to go and how to get there. We give you important tools to help you chart your course and stay on track to reach your destination.