Conversion of adult pancreatic alpha cells to beta cells might be the breakthrough researchers have been looking for. Researchers at University of Pennsylvania Medical School found a way to modify cell nuclear material (chromatin) to induce the expression of beta cell genes in alpha cells.
“We treated human islet cells with a chemical that inhibits a protein that puts methyl chemical groups on histones, which — among many other effects — leads to removal of some histone modifications that affect gene expression,” says Kaestner.
“We then found a high frequency of alpha cells that expressed beta-cell markers, and even produced some insulin, after drug treatment. Diabetics regaining their insulin producing beta cell function could mean a lesser need for synthetic insulin and other diabetic medication.
According to lead author Klaus H. Kastner, “This would be a win-win situation for diabetics; they would have more insulin-producing beta cells and there would be fewer glucagon-producing alpha cells.”
Health-e-Solutions comment: This does not appear to be a very natural means by which to achieve better #BloodSugarControl. We’d have to see many years of safety and efficacy before we would consider an approach like this. We will stick with the Health-e-Solutions lifestyle to #MasterDiabetesNaturally until something safer, better and more natural comes along.
Our recipe e-books, workshops, home study course, support services, and Natural Solutions will teach you how to transform your lifestyle in a practical and livable way for long term health and optimal #BloodSugarControl and better living. You will enjoy a natural way to help #ControlType1Diabetes and type 2 diabetes with healthy, natural, whole, #VeryLowGlycemic foods. While Health is critically important, Outlook, Planning and Evaluation are also part of our framework of HOPE. Cultivating a lifestyle that seeks to improve these four foundational principles will take you far on the road toward a thriving life.
Nuria C. Bramswig, Logan J. Everett, Jonathan Schug, Craig Dorrell, Chengyang Liu, Yanping Luo, Philip R. Streeter, Ali Naji, Markus Grompe, Klaus H. Kaestner. Epigenomic Plasticity Enables Human Pancreatic Alpha-to-Beta Cell Reprogramming. Journal of Clinical Investigation, 2013; doi: 10.1172/JCI66514